As many as 4 percent of electronic prescriptions for non-controlled drugs in 2019 were transfers from one pharmacy to another, according to a CMS estimate that the Drug Enforcement Administration cited in a July 2023 final rule1. A footnote in the rule describes it as a "high" estimate. Applied to controlled substances, it worked out to as many as 13.7 million transfers a year, the agency calculated.
That 2023 rule changed what could move. Until it took effect on Aug. 28, 2023, DEA regulations did not permit an electronic prescription for a Schedule II to V drug to move from one retail pharmacy to another for its first fill, the agency wrote. A patient whose pharmacy could not fill an electronic prescription for a controlled drug had to call the prescriber and ask for a new one to be sent elsewhere.
People move prescriptions for ordinary reasons: the pharmacy is out of stock, another store quotes a lower cash price, the patient has moved, or a plan prefers a different pharmacy. The rules on how it happens are set mostly by state pharmacy boards, with an extra federal layer for controlled substances.
What happens in a transfer
A transfer is a pharmacy-to-pharmacy handoff. The patient does not carry anything. One pharmacy contacts the other, the original pharmacy cancels its copy so it cannot be filled twice, and the new one records the prescription with the details it needs to keep filling it.
Ohio's rule, Ohio Administrative Code 4729:5-5-116, is a useful example because it spells the steps out. The transferring pharmacy must invalidate its copy, record where it went, and note the date and who sent it. The copy sent over must include the prescription number, the transferring pharmacy's name and address, the date the prescription was written, the date of the last refill, the number of refills or quantity remaining, and the name of the person who transferred it. In Ohio, certified pharmacy technicians and pharmacy interns can handle some transfers under supervision. Other states write their own versions, and some differ on who may send or receive one.
Ohio's rule also states a principle that patients rarely see in writing: "Information on a prescription is the property of the patient." Unless another law prohibits it, "no pharmacy shall refuse to transfer information about a prescription to another pharmacy when requested by the patient or patient's caregiver," and the transfer is to happen "as soon as possible to ensure that the patient's drug therapy is not interrupted." A transfer may happen only at the patient's or caregiver's request or with their consent.
How to start one
Because the receiving pharmacy has to record those details, it moves faster when the patient has them on hand. Most of them are on the old label, as our guide to reading a prescription label shows. The details worth having ready are:
- the name and phone number of the pharmacy that has the prescription now;
- the prescription number from the label;
- the drug name and strength, as printed on the label;
- the patient's name and date of birth, and insurance details if the plan will be billed;
- whether the patient wants it filled right away or held until the next refill is due.
A patient comparing prices can ask the new pharmacy for its price before the transfer is made, since moving a prescription does not oblige anyone to fill it. Our guides on asking for the cash price and on why the same generic costs different amounts explain the gaps. Federal benchmark data put the floor in perspective. In October 2026, pharmacies paid an average of 44 cents for 30 tablets of metformin 500 mg, according to CMS NADAC data8. GxRadar's pharmacy finder lists pharmacies registered in the federal NPI registry by ZIP code.
Controlled substances follow federal limits
For drugs on DEA's schedules, federal rules apply on top of state law, and they allow a transfer only "if allowable under existing State or other applicable law." The limits depend on the schedule and on whether the prescription has been filled before.
| Prescription type | Transfer allowed | Federal rule |
|---|---|---|
| Non-controlled drug | Set by state law; no DEA limit | State pharmacy rules |
| Schedule III, IV or V, for refills | One time only, unless the pharmacies share a real-time online database, in which case refills can move up to the number authorized | 21 CFR 1306.25 |
| Schedule II to V electronic prescription, never filled | One time, retail pharmacy to retail pharmacy, at the patient's request, kept in electronic form; refills on a III to V prescription move with it | 21 CFR 1306.08(e) and (f), effective Aug. 28, 2023 |
| Schedule II, after the first fill | Nothing to transfer; refills of Schedule II prescriptions are prohibited | 21 CFR 1306.12(a) |
| Schedule III or IV, any transfer | Still capped at five refills and six months from the date written | 21 CFR 1306.22(a) |
Sources: 21 CFR 1306.252, 21 CFR 1306.083, 21 CFR 1306.125, 21 CFR 1306.224.
Both pharmacists must speak to each other directly for a controlled-substance transfer under 1306.252. For the electronic first-fill transfers added in 2023, 1306.08(f)3 says the prescription must stay in its electronic form and no intermediary may convert it, for example to a fax. Any change to its contents in transit makes it invalid. Both pharmacies must keep records of the transfer for two years.
Schedule II drugs work differently. Because they cannot be refilled, a prescriber who wants a patient to have more than one fill can write separate prescriptions covering up to a 90-day supply, each marked with the earliest date it may be filled, under 1306.12(b)5. The 2023 rule lets an unfilled one of those move once, if state law permits.
When a transfer will not work
A prescription with no refills left has nothing to move, and neither does one past the refill window that state rules allow. In those cases the new pharmacy needs a fresh prescription from the prescriber. Some states let a pharmacist give a short emergency supply when the prescriber cannot be reached. Ohio's law, Revised Code 4729.2817, allows a single 72-hour supply in most cases, with larger amounts for some non-controlled drugs. That is a separate process from a transfer.
A second limit is the controlled-substance cap. A Schedule III to V prescription that has already been transferred once for refills generally cannot be moved again unless the pharmacies share a real-time database. The same is true of an unfilled Schedule II to V electronic prescription after its one permitted transfer. A patient who needs to change pharmacies again usually needs a new prescription, which is a question for the prescriber.
Insurance can also shape the choice. A plan may cover a prescription only at network pharmacies, or charge less at some than at others, and a transfer does not change those terms. A patient switching to a mail-order pharmacy or a store outside the network can ask the plan what the copay would be before the move. When the reason for moving is a shortage, our piece on what to ask when a medicine is in shortage and the FDA shortage tracker show which products are affected.
Under Ohio's rule, at least, the original pharmacy may not refuse once the patient asks, and the receiving side must use "reasonable diligence" to confirm the copy is valid before it is filled.
Sources and notes
- Federal Register (2023). DEA, Transfer of Electronic Prescriptions for Schedules II-V Controlled Substances Between Pharmacies for Initial Filling, 88 FR 48365
www.govinfo.gov/content/pkg/FR-2023-07-27/pdf/2023-15847.pdf - GPO (2025). 21 CFR 1306.25, Transfer between pharmacies of prescription information for Schedules III, IV, and V controlled substances for refill purposes (Code of Federal Regulations, April 1, 2025 edition)
www.govinfo.gov/content/pkg/CFR-2025-title21-vol9/pdf/CFR-2025-title21-vol9-sec1306-25.pdf - GPO (2025). 21 CFR 1306.08, Electronic prescriptions (Code of Federal Regulations, April 1, 2025 edition)
www.govinfo.gov/content/pkg/CFR-2025-title21-vol9/pdf/CFR-2025-title21-vol9-sec1306-08.pdf - GPO (2025). 21 CFR 1306.22, Refilling of prescriptions (Code of Federal Regulations, April 1, 2025 edition)
www.govinfo.gov/content/pkg/CFR-2025-title21-vol9/pdf/CFR-2025-title21-vol9-sec1306-22.pdf - GPO (2025). 21 CFR 1306.12, Refilling prescriptions; issuance of multiple prescriptions (Code of Federal Regulations, April 1, 2025 edition)
www.govinfo.gov/content/pkg/CFR-2025-title21-vol9/pdf/CFR-2025-title21-vol9-sec1306-12.pdf - State of Ohio. Ohio Administrative Code 4729:5-5-11, Prescription copy
codes.ohio.gov/ohio-administrative-code/rule-4729:5-5-11 - State of Ohio (2022). Ohio Revised Code 4729.281, Conditions for refill of prescription
codes.ohio.gov/ohio-revised-code/section-4729.281 - CMS (2026). NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov
data.medicaid.gov/dataset/fbb83258-11c7-47f5-8b18-5f8e79f7e704
Superscript numbers in the text link to these sources. GxRadar data (NADAC histories, recall and shortage counts) come from CMS and FDA files described on the sources page. Researched and drafted with AI assistance and checked against the sources above. Information current as of Nov 3, 2026 and may change. Spot an error? It will be corrected once confirmed.
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