Bisoprolol fumarate and hydrochlorothiazide tablets
Reason category: Impurities (e.g. nitrosamines)
FDA recall number D-0301-2026
Blood pressure
Hydrochlorothiazide 25 mg tablet
Public data on hydrochlorothiazide from CMS and FDA: what pharmacies have paid for it, how many generic applications FDA has approved, and whether it appears in FDA's shortage or recall records.
$0.0114
NADAC per ea (2026-11)
approximate acquisition cost, not a retail price
-23%
change over five years
peak $0.0200 in 2013-11
76
approved generic applications (ANDAs) on record for Hydrochlorothiazide
16 with a product still marketed · first 1973
Listed
in FDA's current shortage list
Quinapril/Hydrochlorothiazide Tablet: Current; Hydrochlorothiazide Capsule: To Be Discontinued
NADAC per unit, monthly
HYDROCHLOROTHIAZIDE 25 MG TABShow as table
| Month | NADAC per unit ($) |
|---|---|
| 2013-11 | 0.01997 |
| 2014-02 | 0.01750 |
| 2014-05 | 0.01622 |
| 2014-08 | 0.01563 |
| 2014-11 | 0.01570 |
| 2015-02 | 0.01509 |
| 2015-05 | 0.01370 |
| 2015-08 | 0.01254 |
| 2015-11 | 0.01204 |
| 2016-02 | 0.01275 |
| 2016-05 | 0.01208 |
| 2016-08 | 0.01322 |
| 2016-11 | 0.01238 |
| 2017-02 | 0.01218 |
| 2017-05 | 0.01173 |
| 2017-08 | 0.01179 |
| 2017-11 | 0.01112 |
| 2018-02 | 0.01076 |
| 2018-05 | 0.00945 |
| 2018-08 | 0.00903 |
| 2018-11 | 0.00843 |
| 2019-02 | 0.00925 |
| 2019-05 | 0.01029 |
| 2019-08 | 0.01384 |
| 2019-11 | 0.01380 |
| 2020-02 | 0.01382 |
| 2020-05 | 0.01458 |
| 2020-08 | 0.01413 |
| 2020-11 | 0.01394 |
| 2021-02 | 0.01364 |
| 2021-05 | 0.01444 |
| 2021-08 | 0.01475 |
| 2021-11 | 0.01482 |
| 2022-02 | 0.01381 |
| 2022-05 | 0.01351 |
| 2022-08 | 0.01334 |
| 2022-11 | 0.01335 |
| 2023-02 | 0.01215 |
| 2023-05 | 0.01315 |
| 2023-08 | 0.01312 |
| 2023-11 | 0.01291 |
| 2024-02 | 0.01300 |
| 2024-05 | 0.01122 |
| 2024-08 | 0.01200 |
| 2024-11 | 0.01094 |
| 2025-02 | 0.01158 |
| 2025-05 | 0.01266 |
| 2025-08 | 0.01261 |
| 2025-11 | 0.01238 |
| 2026-02 | 0.01218 |
| 2026-05 | 0.01210 |
| 2026-08 | 0.01180 |
| 2026-11 | 0.01142 |
Source: CMS NADAC weekly files, generic rows, monthly median of weekly averages · data as of 2026-11. Figures can change and may contain errors in the source data. Check the original source before relying on them.
Recall records mentioning hydrochlorothiazide
openFDA enforcement records, by year reported.
| 2026 | 1 |
| 2025 | 2 |
| 2024 | 3 |
| 2023 | 3 |
| 2022 | 24 |
| 2021 | 5 |
| 2020 | 4 |
| 2019 | 28 |
| 2018 | 37 |
| 2016 | 3 |
133 records since 2012. A record is one product or lot, not one recall event. Combination products that contain hydrochlorothiazide are included.
What these numbers mean
NADAC is what retail pharmacies pay on average to buy the drug, published by CMS. It does not include rebates and is not what you pay at the counter. ANDA counts include all strengths and forms and applications whose products are now discontinued.
Most recent recall records
Bisoprolol fumarate and hydrochlorothiazide tablets
Reason category: Sterility / contamination
FDA recall number D-0199-2026
Lisinopril and hydrochlorothiazide tablets
Reason category: Sterility / contamination
FDA recall number D-0532-2025
Losartan potassium and hydrochlorothiazide tablets
Reason category: Sterility / contamination
FDA recall number D-0498-2024
Triamterene and hydrochlorothiazide capsules
Reason category: Labeling or packaging error
FDA recall number D-0199-2024
Not health advice. GxRadar is for general information only. Nothing here is medical, pharmacy, legal or financial advice. Do not start, stop or change any medicine based on this site. Talk to your pharmacist or prescriber about your own situation.
Articles that mention hydrochlorothiazide
9 GxRadar articles cite or discuss this drug.
Price histories · Data story · 5 min
The cheapest pills in GxRadar's 47-drug price basket
Seven of the 47 generics we track cost pharmacies under 2 cents a unit in October 2026, led by amlodipine at 1.02 cents. Which drugs sit at the floor, how long they have been there, and what the ranking does not show.
Price histories · Data story · 5 min
What pharmacies pay for seven blood pressure generics, 2014 and 2026
At federal survey rates, 365 tablets each of seven common blood pressure generics cost pharmacies about $95 in October 2026, down from $1,403 in October 2014. One drug explains most of the drop.
Equivalence & alternatives · Explainer · 6 min
The 505(b)(2) pathway, between brand and generic
How FDA's hybrid new drug application works, how it differs from a full NDA and a generic ANDA, and what three years of approval data show about who uses it.
Case histories · History · 6 min
How a carcinogen in blood pressure pills changed generic drug testing
Since 2018, nitrosamine impurities have produced nearly 500 federal recall records, pushed ranitidine off the US market and led FDA to set daily intake limits for impurities formed from the drug itself.
Benchmarks & how prices are set · Explainer · 5 min
Average manufacturer price, the confidential number behind Medicaid drug rebates
AMP is the price drugmakers report to Medicaid each month. It sets rebates, triggers inflation penalties and anchors federal payment caps, yet no single company's figure can be made public.
Benchmarks & how prices are set · Explainer · 6 min
The federal upper limit, Medicaid's ceiling on generic drug payments
The FUL caps Medicaid spending on generics at 175 percent of average manufacturer prices, or at pharmacy cost when that is higher. In October 2026 the pharmacy-cost floor set it for 59 percent of drug groups.