Updated Nov 4, 2026FDA and CMS public dataIndependent · free · not health advice
GxRadar
Drugs/Estradiol 1 mg tablet
Hormone

Estradiol 1 mg tablet

Public data on estradiol from CMS and FDA: what pharmacies have paid for it, how many generic applications FDA has approved, and whether it appears in FDA's shortage or recall records.

$0.0632
NADAC per ea (2026-11)
approximate acquisition cost, not a retail price
-32%
change over five years
peak $0.1447 in 2017-08
51
approved generic applications (ANDAs) on record for Estradiol
37 with a product still marketed · first 1975
Not listed
in FDA's current shortage list
no matching FDA shortage entries

NADAC per unit, monthly

ESTRADIOL 1 MG TABLET
Show as table
MonthNADAC per unit ($)
2013-110.07564
2014-020.07783
2014-050.07728
2014-080.07320
2014-110.07591
2015-020.07501
2015-050.07528
2015-080.12170
2015-110.12074
2016-020.12437
2016-050.11868
2016-080.13038
2016-110.12613
2017-020.13470
2017-050.13031
2017-080.14466
2017-110.13559
2018-020.13362
2018-050.12663
2018-080.13264
2018-110.11690
2019-020.11578
2019-050.11512
2019-080.12506
2019-110.11464
2020-020.11799
2020-050.10825
2020-080.10931
2020-110.10659
2021-020.10697
2021-050.10755
2021-080.10418
2021-110.09322
2022-020.09650
2022-050.09081
2022-080.08616
2022-110.08296
2023-020.08848
2023-050.08391
2023-080.08143
2023-110.07970
2024-020.08026
2024-050.06777
2024-080.06817
2024-110.06542
2025-020.06383
2025-050.06871
2025-080.06858
2025-110.07026
2026-020.06916
2026-050.06588
2026-080.06397
2026-110.06317

Source: CMS NADAC weekly files, generic rows, monthly median of weekly averages · data as of 2026-11. Figures can change and may contain errors in the source data. Check the original source before relying on them.

Recall records mentioning estradiol

openFDA enforcement records, by year reported.

202612
20253
20248
20235
20223
202116
20209
201914
201834
201720

299 records since 2012. A record is one product or lot, not one recall event. Combination products that contain estradiol are included.

What these numbers mean

NADAC is what retail pharmacies pay on average to buy the drug, published by CMS. It does not include rebates and is not what you pay at the counter. ANDA counts include all strengths and forms and applications whose products are now discontinued.

Most recent recall records

Class IIOngoing
Estradiol transdermal gel
Reason category: Other
FDA recall number D-0873-2026
Class IIOngoing
Norethindrone and ethinyl estradiol tablets
Reason category: Impurities (e.g. nitrosamines)
FDA recall number D-0588-2026
Class IIOngoing
Estradiol gel
Reason category: Other
FDA recall number D-0543-2026
Class IIOngoing
Estradiol product
Reason category: Sterility / contamination
FDA recall number D-0315-2026
Class IIOngoing
Estradiol product
Reason category: Sterility / contamination
FDA recall number D-0311-2026

Not health advice. GxRadar is for general information only. Nothing here is medical, pharmacy, legal or financial advice. Do not start, stop or change any medicine based on this site. Talk to your pharmacist or prescriber about your own situation.

Articles that mention estradiol

3 GxRadar articles cite or discuss this drug.

Labels & identifiers · Explainer · 6 min

Boxed warnings, FDA's most prominent label warning, explained

What 21 CFR 201.57 requires of a boxed warning, how many prescription labels carry one (about a third, by two counts 14 years apart), and why a generic's box matches the brand's.

Equivalence & alternatives · Explainer · 5 min

Complex generics and why some drugs still have few or no copies

Inhalers, peptide injections, creams and long-acting shots are hard to copy. What FDA counts as complex, how its product-specific guidances and pre-ANDA meetings work, and what recent approvals show.

Labels & identifiers · Explainer · 5 min

Medication Guides and patient package inserts

What 21 CFR Part 208 requires, when a pharmacy must hand over a Medication Guide, how patient package inserts differ, and where FDA's one-page replacement proposal stands.